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Common ones may include mild gastrointestinal issues like nausea or discomfort

After vigorous vortexing, this solution was centrifuged (7000 g for 5 min) and then the bottom layer was collected for spectroscopic analysis and diluted in HCl 3M/MeOH 1:3

10.1016/S0140-6736(21)01921-8 55

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But I dont believe thats been studied in a rigorous way. Rather than developing a dosage off-ramp, other experts argue that these drugs should be treated like any other chronic disease medication